Heterocycles, Vol. 43, No. 6, pp. 1223-1228, 1996
TOTAL SYNTHESIS OF (±)-GERICUDRANIN A
Yoon-Jung Choi, Pil-Jong Shim, Kyung-Soo Ko+, and Hee-Doo Kim*
College of Pharmacy, Sookmyung Women's University,Yongsan-Ku, Seoul 140-742, Korea and Hankook Sinyak Pharmaceutical Co.Ltd.,+ Seo-Ku, Daejeon 610-7, Korea.
Abstract. An efficient and first total synthesis of (±)-gericudranin A is described. Trihydroxyacetophenone was converted to (±)-gericudranin A in seven steps via sequential protection, aldol condensation, epoxidation, cationic cyclization, regioselective C-benzylation and deprotection.